FATE OF TRITIUM LABELED GM1 GANGLIOSIDE INJECTED IN MICE

被引：70

作者：

ORLANDO, P ^{[1
]}

COCCIANTE, G ^{[1
]}

IPPOLITO, G ^{[1
]}

MASSARI, P ^{[1
]}

ROBERTI, S ^{[1
]}

TETTAMANTI, G ^{[1
]}

机构：

[1] UNIV MILAN,IST CHIM BIOL,I-20133 MILAN,ITALY

来源：

PHARMACOLOGICAL RESEARCH COMMUNICATIONS | 1979年 / 11卷 / 09期

关键词：

D O I：

10.1016/S0031-6989(79)80047-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

3H labeled GM1 ganglioside has been injected in mice intravenously, subcutaneously or intramuscularly. Absorbtion, organ and cellular distribution were studied in different organs (blood, liver, muscle, kidney, spinal cord, brain). 3H-GM1 catabolism and elimination was also investigated. Results show that injected GM1 reaches different organs, binds to cellular membranes, and remains unaltered long after administration. A portion of injected GM1 is catabolized to water. © 1979 The Italian Pharmacological Society.

引用

页码：759 / 773

页数：15

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