CHEMICAL MODIFICATION OF TAIPOXIN AND THE CONSEQUENCES FOR PHOSPHOLIPASE-ACTIVITY, PATHOPHYSIOLOGY, AND INHIBITION OF HIGH-AFFINITY CHOLINE UPTAKE

被引：45

作者：

FOHLMAN, J

EAKER, D

DOWDALL, MJ

LULLMANNRAUCH, R

SJODIN, T

LEANDER, S

机构：

[1] AB FERROSAN,S-38256 4 MALMO,SWEDEN

[2] UNIV NOTTINGHAM HOSP & MED SCH,DEPT BIOCHEM,NG7 2UH NOTTINGHAM,ENGLAND

[3] UNIV KIEL,FACHBEREICH MED,INST ANAT,D-2300 KIEL 1,FED REP GER

[4] UNIV LUND,INST FARMACOL,S-22362 LUND,SWEDEN

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1979年 / 94卷 / 02期

关键词：

D O I：

10.1111/j.1432-1033.1979.tb12922.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Treatment of taipoxin with p‐bromophenacyl bromide resulted in modification of single histidine residues in the α and β subunits. The modification decreased the neurotoxicity (lethality) 350‐fold, but the inhibitory action on high‐affinity choline transport was reduced only threefold. The phospholipase activity and Ca2+‐association constants for taipoxin and its subunits were determined. A model for the neurotoxicity of taipoxin indicates the α subunit as the ultimate cause of the disruption of synaptic transmission. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：531 / 540

页数：10

共 39 条

[1] ACUTE MUSCLE DENERVATION INDUCED BY BETA-BUNGAROTOXIN [J].