ANALYSIS OF CLASTOGENIC EFFECT OF PORTO-ALEGRE DRINKING-WATER SUPPLIES ON MOUSE BONE-MARROW CELLS

被引：4

作者：

GIMMLERLUZ, MC

ERDTMANN, B

BALBUENO, RA

机构：

[1] Departamento de Genética, Institiito de Biodências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS

来源：

MUTATION RESEARCH | 1992年 / 279卷 / 04期

关键词：

CLASTOGENICITY; DRINKING WATER; CHROMOSOME DAMAGE;

D O I：

10.1016/0165-1218(92)90237-T

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Studies were conducted to evaluate the clastogenic activity of drinking water from Porto Alegre and Guaiba (Rio Grande do Sul, Brazil) estuarine waters. Mouse bone marrow was the target organ. C57B1/6 male and female mice received the water samples as their only liquid supply. Bone marrow cells were collected on the 16th day after the beginning of treatment. The analysis of metaphases demonstrated that the water supplies did not increase the structural chromosome aberration frequencies compared to the control groups. Concerning numerical alterations, only one treated female group showed a significant difference (loss of one chromosome) when compared to the control group, but this result is not considered relevant.

引用

页码：227 / 231

页数：5

共 31 条

[1] INVIVO GENOTOXICITY OF NITRATES AND NITRITES IN GERM-CELLS OF MALE-MICE .1. EVIDENCE FOR GONADAL EXPOSURE AND LACK OF HERITABLE EFFECTS [J].

ALAVANTIC, D ;

SUNJEVARIC, I ;

PECEVSKI, J ;

BOZIN, D ;

CEROVIC, G .

MUTATION RESEARCH, 1988, 204 (04) :689-695

[2] ACTIVITY OF 1,1,1-TRICHLOROACETONES AND 1,1,3-TRICHLOROACETONES IN A CHROMOSOMAL ABERRATION ASSAY IN CHO CELLS AND THE MICRONUCLEUS AND SPERMHEAD ABNORMALITY ASSAYS IN MICE [J].

BLAZAK, WF ;

MEIER, JR ;

STEWART, BE ;

BLACHMAN, DC ;

DEAHL, JT .

MUTATION RESEARCH, 1988, 206 (04) :431-438

[3] GENOTOXIC PROPERTIES OF HALOACETONITRILES - DRINKING-WATER BY-PRODUCTS OF CHLORINE DISINFECTION [J].

DANIEL, FB ;

SCHENCK, KM ;

MATTOX, JK ;

LIN, ELC ;

HAAS, DL ;

PEREIRA, MA .

FUNDAMENTAL AND APPLIED TOXICOLOGY, 1986, 6 (03) :447-453

[4]

DECAT G, 1985, CR SOC BIOL, V179, P480

[5] CONTRIBUTION OF CHLORINATION TO THE MUTAGENIC ACTIVITY OF DRINKING-WATER EXTRACTS IN SALMONELLA AND CHINESE-HAMSTER OVARY CELLS [J].

DOUGLAS, GR ;

NESTMANN, ER ;

LEBEL, G .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1986, 69 :81-87

[6] GENOTOXIC EVALUATION OF CHRONIC FLUORIDE EXPOSURE - MICRONUCLEUS AND SPERM MORPHOLOGY STUDIES [J].

DUNIPACE, AJ ;

ZHANG, W ;

NOBLITT, TW ;

LI, Y ;

STOOKEY, GK .

JOURNAL OF DENTAL RESEARCH, 1989, 68 (11) :1525-1528

[7] THE EFFECT OF THE PYRROLIZIDINE ALKALOID INTEGERRIMINE ON THE CHROMOSOMES OF MOUSE BONE-MARROW CELLS [J].

GIMMLERLUZ, MC ;

ERDTMANN, B ;

BALBUENO, RA .

MUTATION RESEARCH, 1990, 241 (03) :297-304

[8] DETECTION OF MUTAGENICITY IN DRINKING-WATER USING A MICRONUCLEUS TEST IN NEWT LARVAE (PLEURODELES-WALTL) [J].

JAYLET, A ;

GAUTHIER, L ;

FERNANDEZ, M .

MUTAGENESIS, 1987, 2 (03) :211-214

[9] TABLES FOR DETERMINING STATISTICAL SIGNIFICANCE OF MUTATION FREQUENCIES [J].

KASTENBAUM, MA ;

BOWMAN, KO .

MUTATION RESEARCH, 1970, 9 (05) :527-+

[10]

LIMSYLIANCO CY, 1986, PHILIPP J SCI, V115, P243

← 1 2 3 4 →