Genomic imprinting: developmental significance and molecular mechanism

被引：42

作者：

Surani, M. Azim ^{[1
]}

机构：

[1] AFRC Inst Anim Physiol & Genet Res, Dept Mol Embryol, Cambridge CB2 4AT, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1991年 / 1卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(05)80077-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Imprinting results in the preferential expression of either the maternal or the paternal allele of certain genes, and has a critical influence on the regulation of mammalian development. The identification of specific imprinted chromosomal regions and genes is being used to unravel the molecular mechanism of imprinting and the developmental significance of the non-random expression of parental alleles.

引用

页码：241 / 246

页数：6

共 32 条

[1] EPIGENETIC CONTROL OF TRANSGENE EXPRESSION AND IMPRINTING BY GENOTYPE-SPECIFIC MODIFIERS [J].

ALLEN, ND ;

NORRIS, ML ;

SURANI, MA .

CELL, 1990, 61 (05) :853-861

[2]

BABINET C, 1990, DEVELOPMENT, P81

[3] THE MOUSE INSULIN-LIKE GROWTH-FACTOR TYPE-2 RECEPTOR IS IMPRINTED AND CLOSELY LINKED TO THE TME LOCUS [J].

BARLOW, DP ;

STOGER, R ;

HERRMANN, BG ;

SAITO, K ;

SCHWEIFER, N .

NATURE, 1991, 349 (6304) :84-87

[4] PARENTAL IMPRINTING OF THE MOUSE H19 GENE [J].

BARTOLOMEI, MS ;

ZEMEL, S ;

TILGHMAN, SM .

NATURE, 1991, 351 (6322) :153-155

[5]

Barton S C, 1991, Development, V113, P679

[6]

Beechey C. V., 1991, Mouse Genome, P60

[7] A GENE FROM THE REGION OF THE HUMAN X-INACTIVATION CENTER IS EXPRESSED EXCLUSIVELY FROM THE INACTIVE X-CHROMOSOME [J].

BROWN, CJ ;

BALLABIO, A ;

RUPERT, JL ;

LAFRENIERE, RG ;

GROMPE, M ;

TONLORENZI, R ;

WILLARD, HF .

NATURE, 1991, 349 (6304) :38-44

[8] ECTOPIC EXPRESSION OF THE H19 GENE IN MICE CAUSES PRENATAL LETHALITY [J].

BRUNKOW, ME ;

TILGHMAN, SM .

GENES & DEVELOPMENT, 1991, 5 (06) :1092-1101

[9]

CATTANACH BM, 1990, DEVELOPMENT, P63

[10] A GROWTH-DEFICIENCY PHENOTYPE IN HETEROZYGOUS MICE CARRYING AN INSULIN-LIKE GROWTH FACTOR-II GENE DISRUPTED BY TARGETING [J].

DECHIARA, TM ;

EFSTRATIADIS, A ;

ROBERTSON, EJ .

NATURE, 1990, 345 (6270) :78-80

← 1 2 3 4 →