POTENTIATION OF BLEOMYCIN BY THE AMINOTHIOL WR-1065 IN ASSAYS FOR CHROMOSOMAL DAMAGE IN G(0) HUMAN-LYMPHOCYTES

被引：22

作者：

HOFFMANN, GR ^{[1
]}

SAYER, AM ^{[1
]}

LITTLEFIELD, LG ^{[1
]}

机构：

[1] OAK RIDGE INST SCI & EDUC,DIV MED SCI,OAK RIDGE,TN

来源：

MUTATION RESEARCH | 1994年 / 307卷 / 01期

关键词：

BLEOMYCIN; WR-1065; AMINOTHIOL; RADIOPROTECTOR; MICRONUCLEUS; ABERRATIONS; FISH; CHROMOSOME PAINTING; LYMPHOCYTES; G(0);

D O I：

10.1016/0027-5107(94)90301-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The aminothiol radioprotector WR-1065 potentiates the induction of chromosome aberrations and micronuclei by the chemotherapy drug bleomycin in G(0) human lymphocytes. Potentiation by 5 mM WR-1065 was observed at bleomycin concentrations from 0.1 to 100 mu g/ml in a 2-h treatment. The frequencies of micronuclei induced by bleomycin in the presence of WR-1065 reached that of 500-fold higher concentrations of bleomycin alone. The potential therapeutic implications of these findings are discussed.

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页码：273 / 283

页数：11

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