GLYCOGEN PHOSPHOROLYSIS CAN FORM A METABOLIC SHUTTLE TO SUPPORT CA2+ UPTAKE BY SARCOPLASMIC-RETICULUM MEMBRANES IN SKELETAL-MUSCLE

被引：19

作者：

CUENDA, A

NOGUES, M

GUTIERREZMERINO, C

DEMEIS, L

机构：

[1] UNIV EXTREMADURA, FAC CIENCIAS, DEPT BIOQUIM & BIOL MOLEC, E-06080 BADAJOZ, SPAIN

[2] UNIV FED RIO DE JANEIRO, INST CIENCIAS BIOMED, DEPT BIOQUIM, BR-21941590 RIO DE JANEIRO, BRAZIL

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 196卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.2368

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the presence of glycogen, ADP, phosphoglucomutase and hexokinase, the glycogen phosphorylase b activity associated to sarcoplasmic reticulum (SR) membranes stimulates Ca2+ uptake by SR membrane fragments in the absence of added ATP. Phosphoglucomutase and hexokinase lead to the formation of glucose 6-phosphate which in turn is used as an ATP regenerating system by the Ca2+ pump. It is proposed that a raise of cytosolic AMP and ADP concentrations after muscle contraction can activate an alternative metabolic route which would be used to ensure the maintenance of a low cytosolic Ca2+ concentration and avoid unnecessary metabolic energy depletion in muscle cells. © 1993 Academic Press. All rights reserved.

引用

页码：1127 / 1132

页数：6

共 18 条

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