REVERSIBLE RENAL-FAILURE IN RENAL-TRANSPLANT PATIENTS RECEIVING ORAL ACYCLOVIR PROPHYLAXIS

被引：17

作者：

AHMAD, T ^{[1
]}

SIMMONDS, M ^{[1
]}

MCIVER, AG ^{[1
]}

MCGRAW, ME ^{[1
]}

机构：

[1] SOUTHMEAD GEN HOSP,DEPT PAEDIAT,BRISTOL,AVON,ENGLAND

来源：

PEDIATRIC NEPHROLOGY | 1994年 / 8卷 / 04期

关键词：

RENAL TRANSPLANTATION; RENAL FAILURE; ACYCLOVIR PROPHYLAXIS;

D O I：

10.1007/BF00856544

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Two children who developed acute renal failure in the immediate post-renal transplantation period are presented. Each was immunosuppressed with cyclosporin and was also receiving oral acyclovir for prophylaxis against cytomegalovirus infection. Renal biopsy findings suggested drug toxicity. Discontinuation of acyclovir coincided with reversal of renal impairment. As cyclosporin levels were at the lower end of the therapeutic range, we believe acyclovir to be the likely causative agent.

引用

页码：489 / 491

页数：3

共 12 条

[1]

Belfour H.H., Chase B.A., Stapleton J.T., Simmons R.L., Fryd D.S., A randomised, placebo controlled trial of acyclovir for the prevention of cytomegalovirus disease in recipients of renal allografts, New England Journal of Medicine, 320, pp. 1381-1387, (1989)

[2]

Snydman D.R., Werner B.G., Heinz-Lacey B., Berardi V.P., Tilney N.L., Kirkman R.L., Milford E.L., Cho S.I., Bush H.L., Levey A.S., Strom T.B., Carpenter C.B., Levey R.H., Harmon W.E., Zimmerman C.E., Shapero M.E., Steinman T., Logerfo F., Idelson B., Scroter G., Levin M.J., McIver J., Lesczynski J., Grady G.F., Use of cytomegalovirus immune globulin to prevent cytomegalovirus disease in renal transplant recipients, N Engl J Med, 317, pp. 1049-1054, (1987)

[3]

Sawyer M.H., Webb E.W., balow E.J., Straus S.E., Acyclovir induced renal failure, Am J Med, 84, pp. 1067-1071, (1988)

[4]

Rashed A., Azadeh B., Abu Romeh S.H., Acyclovir-induced acute tubulo-interstitial nephritis, Nephron, 56, pp. 436-438, (1990)

[5]

Dugandzic R.M., Sketris I.S., Beltsky P., Schlech W.E., Givner M.L., Effect of coadministration of acyclovir and cyclosporin on kidney function and cyclosporin concentration in renal transplant patients, DICP, 25, pp. 316-317, (1991)

[6]

Shulman H., Striker G., Deeg H.J., Kennedy M., Storb R., Thomas E.D., Nephrotoxicity of cyclosporin A after allogeneic marrow transplantation: glomerular thrombosis and tubular injury, N Engl J Med, 305, pp. 1392-1395, (1981)

[7]

Brigden D., Rosling A.E., Woods N.C., Renal function after acyclovir intravenous injections. Acyclovir symposium, Am J Med, 73, pp. 182-185, (1982)

[8]

Stoffel M., Squifflet J.P., Pirson Y., Lamy M., Alexander G.P.J., Effectiveness of oral acyclovir prophylaxis in renal transplant recipients, Transplant Proc, 19, pp. 2190-2193, (1987)

[9]

Johnson P.C., Kumar K., Welsh, Woo J., Kahan B.D., Effects of coadministration of cyciosporin and acyclovir on renal function of renal allograft recipients, Transplantation, 44, pp. 329-331, (1987)

[10]

Shepp D.H., Dandliker P.S., Meyers J.D., Treatment of varicella-zoster virus infection in severely immunocompromised patients

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