HYPOURICEMIA IN THE SYNDROME OF INAPPROPRIATE SECRETION OF ANTI-DIURETIC HORMONE

WHILE evaluating patients with the syndrome of inappropriate secretion of antidiuretic hormone, it became apparent to me that hypouricemia was common during the period of hyponatremia. Review of the literature showed only one report of hypouricemia associated with the syndrome,1 and in recent reviews of hypouricemia in hospital patients, the syndrome was either not mentioned2,3 or not found.4 Therefore, a retrospective study of serum levels of uric acid in hyponatremic patients was performed. The results indicate not only that hypouricemia is the rule in patients with inappropriate secretion of antidiuretic hormone but also that the serum concentrations of urate can. © 1979, Massachusetts Medical Society. All rights reserved.