KINETICS OF PLACENTALLY TRANSFERRED PHENYTOIN AND ITS P-HYDROXYLATED METABOLITES IN NEWBORN-INFANTS

被引：13

作者：

RANE, A ^{[1
]}

HOPPEL, C ^{[1
]}

HOJER, B ^{[1
]}

机构：

[1] HUDDINGE UNIV HOSP,KAROLINSKA INST,DEPT PEDIAT,S-14186 HUDDINGE,SWEDEN

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1979年 / 8卷 / 05期

关键词：

D O I：

10.1111/j.1365-2125.1979.tb01027.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The kinetics of phenytoin and its main metabolites, unconjugated and conjugated 4‐hydroxy‐phenytoin were studied in newborn infants of epileptic mothers that were treated with phenytoin during the pregnancy. 2 In two of the infants phenytoin was eliminated by an apparent zero‐order process followed by an apparent first‐order process. In the other two infants the mode of elimination could not be characterized. 3 The decline of plasma conjugated 4‐hydroxy‐phenytoin was parallel to that of phenytoin. In contrast, the plasma concentration of unconjugated 4‐hydroxy‐phenytoin remained grossly constant during the first 3 to 4 days. 1979 The British Pharmacological Society

引用

页码：465 / 468

页数：4

共 12 条

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[10]

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