2 PATHWAYS OF SIGNAL TRANSDUCTION ARE ACTIVATED IN THE SAME CELL BY DIFFERENT CYTOKINES

被引：4

作者：

BARTON, BE ^{[1
]}

MAYER, R ^{[1
]}

JACKSON, JV ^{[1
]}

CLARK, MA ^{[1
]}

机构：

[1] SCHERING PLOUGH CORP,DEPT IMMUNOL,BLOOMFIELD,NJ 07003

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 1991年 / 13卷 / 1-2期

关键词：

D O I：

10.3109/08923979109019700

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NFS60, a murine leukemia cell line, responds to both interleukin 3 and 6 by proliferating, apparently by different signal transduction pathways. Although stimulation by both cytokines increases the uptake of H-3-arachidonic acid, the response to IL-6 was much faster. Furthermore, the effect of various arachidonic acid metabolites on the response to cytokine was different. PGE2 inhibited IL-6-induced proliferation and potentiated the response to IL-3. Additionally the G proteins which coupled the IL-3 and IL-6 receptor to the proliferative response are probably different, based on the ability of cholera toxin to inhibit the IL-3 but not the IL-6 response. These data are evidence of two pathways of signal transduction.

引用

页码：199 / 218

页数：20

共 28 条

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[2]

ALAM R, 1989, J IMMUNOL, V142, P3431

[3] THE ROLE OF ARACHIDONIC-ACID METABOLISM IN IL-3-INDUCED PROLIFERATION [J].