A STUDY OF THE PROSPECTS FOR A CIPROFLOXACIN PVC COATED WIRE ION-SELECTIVE ELECTRODE BASED ON 4-QUINOLONES

被引：15

作者：

AVSEC, H

GOMISCEK, S

机构：

[1] Department of Chemistry and Chemical Technology, University of Ljubljana

来源：

ANALYTICA CHIMICA ACTA | 1992年 / 268卷 / 02期

关键词：

ION-SELECTIVE ELECTRODES; PVC COATED WIRE ELECTRODES; 4-QUINOLONES;

D O I：

10.1016/0003-2670(92)85225-U

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A potentiometric sensor system characterized by a membrane, based on a molecular dispersion of certain 4-quinolones and dioctylphthalate as a plasticizing solvent mediator in an inert poly(vinyl chloride) (PVC) support, is assessed for the selectivity towards ciprofloxacin (CF) ions. The electrodes which respond to CF ions have been prepared by coating a silver wire conductor with the PVC based film. The preferred system with norfloxacin in the membrane shows a linear response with a Nernstian slope of 54-62 mV/pCF over the range of 1 X 10(-4) to 1 X 10(-2) M solution of CF. The electrode exhibits good selectivity with respect to inorganic ions of biological importance. CF can be determined successfully in its pure solutions and in some pharmaceutical preparations using the standard addition technique.

引用

页码：307 / 309

页数：3

共 13 条

[1]

Andriole V., 1988, QUINOLONES

[2]

AVSEC H, 1990, VESTN SLOV KEM DRUS, V37, P299

[3] COMPARISON OF HIGH-PRESSURE LIQUID-CHROMATOGRAPHY AND MICROBIOLOGICAL ASSAY FOR THE DETERMINATION OF BILIARY ELIMINATION OF CIPROFLOXACIN IN HUMANS [J].