STUDIES ON ANTICANDIDA AGENTS WITH A PYRROLE MOIETY - SYNTHESIS AND MICROBIOLOGICAL ACTIVITY OF SOME 3-AMINOMETHYL-1,5-DIARYL-2-METHYL-PYRROLE DERIVATIVES

被引：22

作者：

CERRETO, F

VILLA, A

RETICO, A

SCALZO, M

机构：

[1] UNIV ROME LA SAPIENZA,DIPARTIMENTO STUDI CHIM & TECNOL SOSTANZE BIOLOGICAMENTE ATT,I-00185 ROME,ITALY

[2] UNIV ROME LA SAPIENZA,FAC FARM,IST MICROBIOL,I-00185 ROME,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 27卷 / 07期

关键词：

PYRROLE; ANTICANDIDA AGENT; N-METHYLPIPERAZINE; PYRROLIDINE; DIMETHYLAMINE; IMIDAZOLE; STRUCTURE-ACTIVITY RELATIONSHIP;

D O I：

10.1016/0223-5234(92)90090-N

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and anti-Candida activity of some 3-aminomethyl-1,5-diaryl-2-methyl-pyrrole derivatives are reported. Some derivatives show a rather strong anti-Candida activity. On the basis of experimental results, microbiological activity of 1,5-diarylpyrroles appears to be mainly related to aminic nitrogen lone pair availability of C3 substituent of the pyrrole nucleus. The C5 and N1 substituents play an important role in modulating biological activity. Some structure-activity relationships are proposed.

引用

页码：701 / 708

页数：8

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