PEPTIDE NUCLEIC-ACIDS CONTAINING ADENINE OR GUANINE RECOGNIZE THYMINE AND CYTOSINE IN COMPLEMENTARY-DNA SEQUENCES

被引：78

作者：

EGHOLM, M

BEHRENS, C

CHRISTENSEN, L

BERG, RH

NIELSEN, PE

BUCHARDT, O

机构：

[1] UNIV COPENHAGEN,HC ORSTED INST,CHEM LAB 2,MED BIOTECHNOL RES CTR,UNIV PK 5,DK-2100 COPENHAGEN,DENMARK

[2] RISO NATL LAB,DEPT MAT,POLYMER GRP,DK-4000 ROSKILDE,DENMARK

[3] PANUM INST,DEPT BIOCHEM B,DK-2200 COPENHAGEN N,DENMARK

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1993年 / 09期

关键词：

D O I：

10.1039/c39930000800

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Peptide nucleic acid (PNA) monomer building blocks for the introduction of G and A are prepared and used to synthesise H-T4XT5-Lys-NH2 (X = G or A), which are shown by T(m) measurements to recognize their complementary DNA sequences in both the parallel (N-terminal PNA/5'-DNA) and the anti-parallel mode; the stoichiometry in each case is (PNA)2/DNA.

引用

页码：800 / 801

页数：2

共 7 条

[1] DNA UNWINDING UPON STRAND-DISPLACEMENT BINDING OF A THYMINE-SUBSTITUTED POLYAMIDE TO DOUBLE-STRANDED DNA [J].