SLEEP DISORDERS IN BIPOLAR DEPRESSION - HYPNOTICS VS SEDATIVE ANTIDEPRESSANTS

被引:8
作者
SAIZRUIZ, J
CEBOLLADA, A
IBANEZ, A
机构
关键词
D O I
10.1016/0022-3999(94)90136-8
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Ninety-six patients with bipolar disorder who attended a lithium clinic were reviewed in a retrospective study. Sleep disorders were studied in 85 depressive episodes. Eighty-one percent of the subjects presented with insomnia; the mixed type being the most frequent (49%) followed by early awakening (25%). The evolution of depression in the patients was compared according to the treatment received for insomnia: sedative antidepressants vs other anxiolytic or hypnotic drugs. Fifteen percent of patients shifted to mania, this group more frequently receiving sedative antidepressants (p<0.05). Moreover, the patients who had received sedative antidepressants as therapy for insomnia (N = 61) showed a tendency to have a shorter asymptomatic interval before the following relapse (13 months vs 19 months; p = 0.06). In view of these results, we consider that the use of sedative antidepressants as a treatment for insomnia during depressive episodes in bipolar patients could be a factor contributing to worse prognoses; in these cases it appears that the use of other hypnotic drugs would be more advisable.
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页码:55 / 60
页数:6
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