THE UP-REGULATION OF TRKA AND TRKB IN DORSAL COLUMN ASTROCYTES FOLLOWING DORSAL RHIZOTOMY

被引：14

作者：

FOSCHINI, DR ^{[1
]}

KESTLER, AM ^{[1
]}

EGGER, MD ^{[1
]}

CROCKETT, DP ^{[1
]}

机构：

[1] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT NEUROSCI & CELL BIOL,NEWARK,NJ 07103

来源：

NEUROSCIENCE LETTERS | 1994年 / 169卷 / 1-2期

关键词：

NEUROGLIA; NEUROTROPHIC FACTOR; PRIMARY AFFERENT; SPINAL CORD; INJURY; DEAFFERENTATION;

D O I：

10.1016/0304-3940(94)90347-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

One week after rat dorsal root fibers were severed, immunoreactivity for the high affinity neurotrophin receptors, trkA and trkB, was up-regulated on glial cells in the spinal cord dorsal column. Immunoreactivity for glial fibrillary acidic protein (GFAP) also increased. In contrast, no changes in immunoreactivity for trkA or trkB, or for GFAP were observed in the brainstem cuneate nucleus, a principal termination site for many of the severed dorsal root fibers.

引用

页码：21 / 24

页数：4

共 18 条

[1] NERVE GROWTH-FACTOR INDUCES PROLIFERATION AND ENHANCES FIBER REGENERATION IN OLIGODENDROCYTES ISOLATED FROM ADULT-PIG BRAIN [J].

ALTHAUS, HH ;

KLOPPNER, S ;

SCHMIDTSCHULTZ, T ;

SCHWARTZ, P .

NEUROSCIENCE LETTERS, 1992, 135 (02) :219-223

[2] THE TRK FAMILY OF TYROSINE PROTEIN-KINASE RECEPTORS [J].

BARBACID, M ;

LAMBALLE, F ;

PULIDO, D ;

KLEIN, R .

BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1072 (2-3) :115-127

[3]

BEROD A, 1981, J HISTOCHEM CYTOCHEM, V29, P884

[4] OLIGODENDROCYTE-ASSOCIATED AND MYELIN-ASSOCIATED INHIBITORS OF NEURITE OUTGROWTH - THEIR INVOLVEMENT IN THE LACK OF CNS REGENERATION [J].

CADELLI, DS ;

BANDTLOW, CE ;

SCHWAB, ME .

EXPERIMENTAL NEUROLOGY, 1992, 115 (01) :189-192

[5]

FOSCHINI D, 1993, PHYSIOLOGIST, V36, pA16

[6]

Foschini D. R., 1993, Society for Neuroscience Abstracts, V19, P1296

[7] CHARACTERIZATION OF GLIAL TRKB RECEPTORS - DIFFERENTIAL RESPONSE TO INJURY IN THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS [J].

FRISEN, J ;

VERGE, VMK ;

FRIED, K ;

RISLING, M ;

PERSSON, H ;

TROTTER, J ;

HOKFELT, T ;

LINDHOLM, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (11) :4971-4975

[8] INCREASED LEVELS OF TRKB MESSENGER-RNA AND TRKB PROTEIN-LIKE IMMUNOREACTIVITY IN THE INJURED RAT AND CAT SPINAL-CORD [J].

FRISEN, J ;

VERGE, VMK ;

CULLHEIM, S ;

PERSSON, H ;

FRIED, K ;

MIDDLEMAS, DS ;

HUNTER, T ;

HOKFELT, T ;

RISLING, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (23) :11282-11286

[9] EXPRESSION OF BETA-NERVE GROWTH-FACTOR IN CULTURED-CELLS DERIVED FROM THE HYPOTHALAMUS AND CEREBRAL-CORTEX [J].

GONZALEZ, D ;

DEES, WL ;

HINEY, JK ;

OJEDA, SR ;

SANETO, RP .

BRAIN RESEARCH, 1990, 511 (02) :249-258

[10] EXPRESSION OF P75NGFR TRKA, AND TRKB MESSENGER-RNA IN RAT-C6 GLIOMA AND TYPE-I ASTROCYTE CULTURES [J].

HUTTON, LA ;

DEVELLIS, J ;

PEREZPOLO, JR .

JOURNAL OF NEUROSCIENCE RESEARCH, 1992, 32 (03) :375-383

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