UREA CYCLE DISORDER IN C3H-H-2-DEGREES MICE WITH JUVENILE STEATOSIS OF VISCERA

被引：35

作者：

IMAMURA, Y ^{[1
]}

SAHEKI, T ^{[1
]}

ARAKAWA, H ^{[1
]}

NODA, T ^{[1
]}

KOIZUMI, T ^{[1
]}

NIKAIDO, H ^{[1
]}

HAYAKAWA, JI ^{[1
]}

机构：

[1] KANAZAWA UNIV,SCH MED,INST EXPTL ANIM,KANAZAWA,ISHIKAWA 920,JAPAN

来源：

FEBS LETTERS | 1990年 / 260卷 / 01期

关键词：

(Animal model); Carbamylphosphate synthetase; Gene expression; Hyperammonemia; Steatosis; Urea cycle;

D O I：

10.1016/0014-5793(90)80081-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We determined the activities of urea cycle enzymes in the liver of C3H-H-2o-jsv mice. The activities of all urea cycle enzymes decreased in the latter period of lactation. The activities of carbamylphosphate synthetase and ornithine transcarbamylase in some affected mice were undetectable. On the other hand, the activities of enzymes other than urea cycle enzymes were normal. We consider that the decrease in the urea cycle enzymes is caused by an abnormality in the mechanism of gene expression. © 1990.

引用

页码：119 / 121

页数：3

共 13 条

[1] Bergmeyer HU, 1974, METHOD ENZYMAT AN, P574
[2] PURIFICATION AND PROPERTIES OF RAT-BRAIN GLUTAMATE-DEHYDROGENASE
CHEE, PY
DAHL, JL
FAHIEN, LA
[J]. JOURNAL OF NEUROCHEMISTRY, 1979, 33 (01) : 53 - &
[3] HAYAKAWA J, 1989, IN PRESS MOUSE NEWS
[4] KATUNUMA N, 1964, J BIOCH, V58, P499
[5] INFANTILE DISEASE WITH MICROVESICULAR FATTY INFILTRATION OF VISCERA SPONTANEOUSLY OCCURRING IN THE C3H-H-2-DEGREE STRAIN OF MOUSE WITH SIMILARITIES TO REYES-SYNDROME
KOIZUMI, T
NIKAIDO, H
HAYAKAWA, J
NONOMURA, A
YONEDA, T
[J]. LABORATORY ANIMALS, 1988, 22 (01) : 83 - 87
[6] EFFECTS OF DELETIONS IN MOUSE CHROMOSOME-7 ON EXPRESSION OF GENES ENCODING THE UREA-CYCLE ENZYMES AND PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) IN LIVER, KIDNEY, AND INTESTINE
MORRIS, SM
MONCMAN, CL
KEPKA, DM
NEBES, VL
DIVEN, WF
DIZIKES, GJ
CEDERBAUM, SD
DEFRANCO, D
[J]. BIOCHEMICAL GENETICS, 1988, 26 (11-12) : 769 - 781
[7] QUALITATIVE AND QUANTITATIVE ABNORMALITIES OF ARGININOSUCCINATE SYNTHETASE IN CITRULLINEMIA
SAHEKI, T
UEDA, A
HOSOYA, M
KUSUMI, K
TAKADA, S
TSUDA, M
KATSUNUMA, T
[J]. CLINICA CHIMICA ACTA, 1981, 109 (03) : 325 - 335
[8] SEGAL HL, 1959, J BIOL CHEM, V234, P1937
[9] SHINDO Y, 1978, BIOCHEM PHARMACOL, V27, P2683
[10] SIBLEY JA, 1949, J BIOL CHEM, V177, P859

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