INDUCTION OF MICRONUCLEI IN V79 CHINESE-HAMSTER CELLS BY TETRACHLOROHYDROQUINONE, A METABOLITE OF PENTACHLOROPHENOL

被引：24

作者：

JANSSON, K ^{[1
]}

JANSSON, V ^{[1
]}

机构：

[1] UNIV JYVASKYLA,DEPT CELL BIOL,SF-40100 JYVASKYLA,FINLAND

来源：

MUTATION RESEARCH | 1992年 / 279卷 / 03期

关键词：

PENTACHLOROPHENOL; TETRACHLOROHYDROQUINONE; HYDROXYL RADICALS; MICRONUCLEI; V79; CELLS;

D O I：

10.1016/0165-1218(92)90068-B

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Tetrachlorohydroquinone, a metabolite of the fungicide pentachlorophenol, induced significant dose-related increases in micronuclei in V79 Chinese hamster cells without exogenous metabolic activation. The lowest observed effective dose was 10-mu-M, where the relative survival was about 62%. At the highest dose tested, 20-mu-M, the relative survival was about 8% and the frequency of cells with micronuclei was about 6 times the solvent control frequency. The induction of micronuclei by tetrachlorohydroquinone was significantly inhibited by the hydroxyl radical scavenger dimethyl sulfoxide at 5% (v/v).

引用

页码：205 / 208

页数：4

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