TRANSPLANTATION OF DISCORDANT XENOGRAFTS - A REVIEW OF PROGRESS

被引：538

作者：

PLATT, JL

VERCELLOTTI, GM

DALMASSO, AP

MATAS, AJ

BOLMAN, RM

NAJARIAN, JS

BACH, FH

机构：

[1] VET ADM MED CTR,MINNEAPOLIS,MN 55417

[2] UNIV MINNESOTA,DEPT PEDIAT,MINNEAPOLIS,MN 55455

[3] UNIV MINNESOTA,DEPT CELL BIOL,MINNEAPOLIS,MN 55455

[4] UNIV MINNESOTA,DEPT NEUROANAT,MINNEAPOLIS,MN 55455

[5] UNIV MINNESOTA,DEPT MED,MINNEAPOLIS,MN 55455

[6] UNIV MINNESOTA,DEPT LAB MED & PATHOL,MINNEAPOLIS,MN 55455

[7] UNIV MINNESOTA,DEPT SURG,MINNEAPOLIS,MN 55455

来源：

IMMUNOLOGY TODAY | 1990年 / 11卷 / 12期

关键词：

D O I：

10.1016/0167-5699(90)90174-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hyperacute rejection, apparently initiated by natural antibodies and complement, has been viewed as an absolute barrier to the xenotransplantation of vascularized grafts between different species. Until recently, little was known about the molecular and physiological basis for this barrier nor was there evidence that the barrier might be more than transiently breached. In this paper Jeffrey Platt, Fritz Bach and colleagues described a model of hyperacute rejection and propose that, if hyperacute rejection can be averted for a period after transplantation, prolonged xenograft survival will be possible.

引用

页码：450 / 456

页数：7

共 59 条

[1]

ALEXANDRE GPJ, 1989, XENOGRAFT, V25, P259

[2]

Alter B J, 1970, Cell Immunol, V1, P207, DOI 10.1016/0008-8749(70)90008-0

[3] CELLULAR BASIS OF THE PROLIFERATIVE RESPONSE OF HUMAN T-CELLS TO MOUSE XENOANTIGENS [J].