DNA HYDROLYZING AUTOANTIBODIES

被引：352

作者：

SHUSTER, AM ^{[1
]}

GOLOLOBOV, GV ^{[1
]}

KVASHUK, OA ^{[1
]}

BOGOMOLOVA, AE ^{[1
]}

SMIRNOV, IV ^{[1
]}

GABIBOV, AG ^{[1
]}

机构：

[1] VA ENGELHARDT MOLEC BIOL INST,VAVILOV STR 32,MOSCOW 117984,USSR

来源：

SCIENCE | 1992年 / 256卷 / 5057期

关键词：

D O I：

10.1126/science.1585181

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A DNA-nicking activity was detected in the sera of patients with various autoimmune pathologies and was shown to be a property of autoantibodies. The DNA hydrolyzing activity, which was purified by affinity and high-performance liquid chromatography, corresponded in size to immunoglobulin M (IgM) and IgG and had a positive response to antibodies to human IgG. The DNA hydrolyzing autoantibodies were stable to acid shock and yielded a DNA degradation pattern that was different from that of deoxyribonuclease (DNase) I and blood DNase.

引用

页码：665 / 667

页数：3

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