SYNTHESIS OF (-)-CHANOCLAVINE-I

被引：26

作者：

KARDOS, N ^{[1
]}

GENET, JP ^{[1
]}

机构：

[1] ECOLE NATL SUPER CHIM,CNRS,SYNTH ORGAN LAB,F-75231 PARIS 05,FRANCE

来源：

TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 08期

关键词：

D O I：

10.1016/0957-4166(94)80122-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The total enantioselective synthesis of (-)-chanoclavine I 2 in twelve steps from indole-4-carboxaldehyde 4 is described The key-step 3 --> 6 which involves the formation of the C ring by creation of the C5-C10 bond is catalyzed by a chiral palladium (0) complexes. The chiral ergoline synthon 6 is produced with an excellent diastereo-and enantioselectivity (up to 95%) eel.

引用

页码：1525 / 1533

页数：9

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