MOSAIC ORGANIZATION OF DNA NUCLEOTIDES

被引：4019

作者：

PENG, CK

BULDYREV, SV

HAVLIN, S

SIMONS, M

STANLEY, HE

GOLDBERGER, AL

机构：

[1] BOSTON UNIV,DEPT PHYS,BOSTON,MA 02215

[2] HARVARD UNIV,BETH ISRAEL HOSP,SCH MED,DIV CARDIOVASC,BOSTON,MA 02215

[3] MIT,DEPT BIOL,CAMBRIDGE,MA 02139

来源：

PHYSICAL REVIEW E | 1994年 / 49卷 / 02期

关键词：

D O I：

10.1103/PhysRevE.49.1685

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

Long-range power-law correlations have been reported recently for DNA sequences containing noncoding regions. We address the question of whether such correlations may be a trivial consequence of the known mosaic structure (''patchiness'') of DNA. We analyze two classes of controls consisting of patchy nucleotide sequences generated by different algorithms-one without and one with long-range power-law correlations. Although both types of sequences are highly heterogeneous, they are quantitatively distinguishable by an alternative fluctuation analysis method that differentiates local patchiness from long-range correlations. Application of this analysis to selected DNA sequences demonstrates that patchiness is not sufficient to account for long-range correlation properties.

引用

页码：1685 / 1689

页数：5

共 17 条

[1] THE MOSAIC GENOME OF WARM-BLOODED VERTEBRATES [J].

BERNARDI, G ;

OLOFSSON, B ;

FILIPSKI, J ;

ZERIAL, M ;

SALINAS, J ;

CUNY, G ;

MEUNIERROTIVAL, M ;

RODIER, F .

SCIENCE, 1985, 228 (4702) :953-958

[2] GLOBAL FRACTAL DIMENSION OF HUMAN DNA-SEQUENCES TREATED AS PSEUDORANDOM WALKS [J].

BERTHELSEN, CL ;

GLAZIER, JA ;

SKOLNICK, MH .

PHYSICAL REVIEW A, 1992, 45 (12) :8902-8913

[3] GENERALIZED LEVY-WALK MODEL FOR DNA NUCLEOTIDE-SEQUENCES [J].

BULDYREV, SV ;

GOLDBERGER, AL ;

HAVLIN, S ;

PENG, CK ;

SIMONS, M ;

STANLEY, HE .

PHYSICAL REVIEW E, 1993, 47 (06) :4514-4523

[4] LONG-RANGE POWER-LAW CORRELATIONS IN DNA [J].

BULDYREV, SV ;

GOLDBERGER, AL ;

HAVLIN, S ;

PENG, CK ;

SIMONS, M ;

SCIORTINO, F .

PHYSICAL REVIEW LETTERS, 1993, 71 (11) :1776-1776

[5]

BULDYREV SV, 1993, BIOPHYS J, V65, P2675

[6]

CHURCHILL GA, 1989, B MATH BIOL, V51, P79

[7] BASE COMPOSITIONAL STRUCTURE OF GENOMES [J].

FICKETT, JW ;

TORNEY, DC ;

WOLF, DR .

GENOMICS, 1992, 13 (04) :1056-1064

[8] CRUMPLED GLOBULE MODEL OF THE 3-DIMENSIONAL STRUCTURE OF DNA [J].

GROSBERG, A ;

RABIN, Y ;

HAVLIN, S ;

NEER, A .

EUROPHYSICS LETTERS, 1993, 23 (05) :373-378

[9]

GROSBERG AY, 1993, BIOFIZIKA, V26, P1

[10] RANDOM MULTIPLICATIVE PROCESSES AND TRANSPORT IN STRUCTURES WITH CORRELATED SPATIAL DISORDER [J].

HAVLIN, S ;

SELINGER, RB ;

SCHWARTZ, M ;

STANLEY, HE ;

BUNDE, A .

PHYSICAL REVIEW LETTERS, 1988, 61 (13) :1438-1441

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