ANTI-DSDNA AND COMPLEMENT PROFILES AS PROGNOSTIC GUIDES IN SYSTEMIC LUPUS-ERYTHEMATOSUS

被引：271

作者：

SWAAK, AJG

AARDEN, LA

STATIUSVANEPS, LW

FELTKAMP, TEW

机构：

[1] UNIV AMSTERDAM,EXPTL & CLIN IMMUNOL LAB,AMSTERDAM 1004,NETHERLANDS

[2] NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,DEPT AUTOIMMUNE DIS,AMSTERDAM,NETHERLANDS

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 03期

关键词：

D O I：

10.1002/art.1780220304

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antibodies to dsDNA, tested with circular DNA in the Farr assay, are specific for systemic lupus erythematosus. A longitudinal study showed a clear relation between the clinical state, the anti‐dsDNA titer (expressed in units), and the C1q and C3 levels: when anti‐dsDNA levels remained high, no exacerbations were observed. A sharp drop in anti‐dsDNA, usually preceded by a rise, was related to a serious exacerbation. Only during the exacerbation when both C1q and C3 were very low was renal involvement seen. Copyright © 1979 American College of Rheumatology

引用

页码：226 / 235

页数：10

共 22 条

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