REDUCTIVE ALKYLATION OF ENAMINES WITH CHLOROMETHYL PARA-TOLYL SULFONE VIA A RADICAL CHAIN PROCESS

被引：38

作者：

RENAUD, P

SCHUBERT, S

机构：

[1] Institut de chimie organique, Université Lausanne, Lausanne, CH-1005, 2, rue de la Barre

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1990年 / 29卷 / 04期

关键词：

D O I：

10.1002/anie.199004331

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyclic cnamines can be alkylatcd diastereoselectively with chloromethyl p‐tolylsulfone. The cis‐selectivity of this radical reaction is especially striking in the formation of cyclohexane derivatives such as 1 (>95%). The rate at which p‐tolylsulfonylmethyl radical adds to the enamine is a function both of its donor characteristics and of steric factors. (Figure Presented.) Copyright © 1990 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：433 / 435

页数：3

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