COMPLEMENT-MEDIATED UNSPECIFIC BINDING OF IMMUNOGLOBULINS TO SOME ENDOCRINE-CELLS

被引：49

作者：

BUFFA, R

CRIVELLI, O

FIOCCA, R

FONTANA, P

SOLCIA, E

机构：

[1] UNIV PAVIA,INST PATHOL ANAT,I-27100 PAVIA,ITALY

[2] OSPED MAURIZIANO,DIV GASTRENTEROL,TORINO,ITALY

来源：

HISTOCHEMISTRY | 1979年 / 63卷 / 01期

关键词：

D O I：

10.1007/BF00508008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Unspecific binding of immunoglobulins to gastrin G cells, glucagon A cells and somatostatin D cells of the gastric mucosa or pancreas, as well as to the calcitonin-somatostatin cells of rabbit thyroid has been found to occur through a non antigen-antibody mechanism mediated at least in part by the C1q fraction of complement. The phenomenon represents a major drawback in hormone immunohistochemistry, which can be prevented by incubating the specific anti-hormone sera with anti-C1q antibodies or with complement-fixing immunocomplexes. © 1979 Springer-Verlag.

引用

页码：15 / 21

页数：7

共 26 条

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