DURATION AND LONG-TERM EFFICACY OF PHENYLEPHRINE-INDUCED REDUCTION IN THE SYSTEMIC ABSORPTION OF OPHTHALMIC TIMOLOL IN RABBITS

被引：4

作者：

JARVINEN, K

URTTI, A

机构：

[1] Department of Pharmaceutical Technology, University of Kuopio, Kuopio

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1992年 / 8卷 / 02期

关键词：

D O I：

10.1089/jop.1992.8.91

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Co-administration of phenylephrine decreases systemic timolol absorption after a single topical ocular dose of timolol in rabbits. This is probably due to vasoconstriction in the conjunctiva of the eye and nasal mucosa. in this study, we evaluated the duration of action and long-term efficacy of phenylephrine in reducing the systemic absorption of ophthalmic timolol in pigmented rabbits. Although co-administered phenylephrine had a short duration of interaction with systemic timolol absorption (20-60 min), its effect on systemic timolol absorption was substantial. The long-term vasoconstrictive effect of phenylephrine was studied by administering timolol-phenylephrine eyedrops into the eyes of rabbits once a day for two months. Systemic peak concentrations of timolol following timolol-phenylephrine eyedrop administration remained unchanged throughout the study. Phenylephrine may be useful additive in decreasing the systemic concentrations of ophthalmic drugs.

引用

页码：91 / 98

页数：8

共 25 条

[1]

Kaila T., Salminen L., Huupponen R., Systemic absorption of topically applied ocular timolol, J.Ocul.Pharmacol, 1, pp. 79-83, (1985)

[2]

Urtti A., Pipkin J.D., Rork G., Sendo T., Finne U., Repta A.J., Controlled drug delivery devices for experimental ocular studies with timolol 2. Ocular and systemic absorption in rabbits, Int.J.Pharm, 61, pp. 241-249, (1990)

[3]

Chang S.C., Lee V.H.L., Nasal and conjunctival contributions to the systemic absorption of topical timolol in the pigmented rabbit: implications in the design of strategies to maximize the ratio of ocular to systemic absorption, J.Ocul.Pharmacol, 3, pp. 159-169, (1987)

[4]

Jarvinen K., Vartiainen E., Urtti A., Optimizing the systemic and ocular absorption of timolol from eyedrops, S.t.p. Pharma Sci, 2, pp. 105-110, (1992)

[5]

Fraunfelder F.T., Meyer M.S., Systemic side effects from ophthalmic timolol and their prevention, J.Ocul.Pharmacol, 3, pp. 177-184, (1987)

[6]

Chang S.C., Bundgaard H., Buur A., Lee V.H.L., Improved corneal penetration of timolol by prodrugs as a means to reduce systemic drug load, Invest. Ophthalmol.Vis.Sci, 28, pp. 487-491, (1987)

[7]

Chang S.C., Chien D.S., Bundgaard H., Lee V.H.L., Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol, Exp.EveRes, 46, pp. 59-69, (1988)

[8]

Kyyronen K., Urtti A., Improved ocular:systemic absorption ratio of timolol by viscous vehicle and phenylephrine, Invest.Ophthalmol.Vis.Sci, 31, pp. 1827-1833, (1990)

[9]

Finne U., Vaisanen V., Urtti A., Modification of ocular and systemic absorption of timolol from ocular inserts by a buffering agent and a vasoconstrictor, Int.J. Pharm, 65, pp. 19-27, (1990)

[10]

Sihvola P., Puustjarvi T., Practical problems in the use of Ocusert-pilocarpine delivery system, Acta Ophthalmol, 58, pp. 933-937, (1980)

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