INTRACRINOLOGY

被引:685
作者
LABRIE, F [1 ]
机构
[1] UNIV LAVAL, DEPT PHYSIOL, QUEBEC CITY G1V 4G2, QUEBEC, CANADA
基金
英国医学研究理事会;
关键词
STEROIDOGENESIS; ANDROGEN; ESTROGEN; ADRENAL PRECURSOR; INTRACRINE;
D O I
10.1016/0303-7207(91)90116-A
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A large proportion of androgens in men (40%), and the majority of estrogens in women (75% before menopause and close to 100% after menopause), are synthesized in peripheral target tissues from precursor steroids of adrenal origin. The genes encoding the formation and metabolism of androgens and estrogens are expressed in a large series of peripheral tissues, thus providing the basis for a promising new area in hormone action, namely intracrinology. These steroidogenic and steroid metabolizing enzymes should become a major target of novel therapies for steroid-sensitive diseases, particularly breast and prostate cancer.
引用
收藏
页码:C113 / C118
页数:6
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