MACROPHAGE TROPISM DETERMINANTS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INVIVO

被引：292

作者：

WESTERVELT, P

TROWBRIDGE, DB

EPSTEIN, LG

BLUMBERG, BM

LI, YX

HAHN, BH

SHAW, GM

PRICE, RW

RATNER, L

机构：

[1] WASHINGTON UNIV, SCH MED, DEPT MED, 660 S EUCLID, ST LOUIS, MO 63110 USA

[2] WASHINGTON UNIV, SCH MED, DEPT MOLEC MICROBIOL, ST LOUIS, MO 63110 USA

[3] UNIV ROCHESTER, MED CTR, DEPT NEUROL, ROCHESTER, NY 14642 USA

[4] UNIV ROCHESTER, MED CTR, DEPT PEDIAT, ROCHESTER, NY 14642 USA

[5] UNIV ROCHESTER, MED CTR, DEPT MICROBIOL, ROCHESTER, NY 14642 USA

[6] UNIV ROCHESTER, MED CTR, DEPT IMMUNOL, ROCHESTER, NY 14642 USA

[7] UNIV ALABAMA, DEPT MED, BIRMINGHAM, AL 35294 USA

[8] UNIV ALABAMA, DEPT MICROBIOL, BIRMINGHAM, AL 35294 USA

[9] UNIV MINNESOTA, SCH MED, DEPT NEUROL, MINNEAPOLIS, MN 55455 USA

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 04期

关键词：

D O I：

10.1128/JVI.66.4.2577-2582.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Strains of human immunodeficiency virus type 1 differ in their abilities to infect and replicate in primary human macrophages. Chimeric clones were constructed from a provirus unable to infect macrophages (NLHX) and envelope sequences (V3 loop) of viruses derived without cultivation from brain (YU2 and w1-1c1) or spleen (w2-1b4) tissues. The substituted V3 loop sequences in each case were sufficient to confer upon NLHX the ability to infect macrophages. Furthermore, an envelope domain immediately N terminal to the V3 loop also was found to modulate the level of replication in macrophages. These results demonstrate that an envelope determinant derived directly from patients with AIDS confers HIV-1 tropism for macrophages.

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页码：2577 / 2582

页数：6

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