A NEW SYNTHESIS OF N-SUBSTITUTED-2-ALKYL-QUINAZOLIN-4-AMINES OR N-SUBSTITUTED-2-ARYL-QUINAZOLIN-4-AMINES BY AMIDE BASE-MEDIATED CYCLIZATION OF CARBOXIMIDAMIDES DERIVED FROM 2-(TRIFLUOROMETHYL)BENZENAMINE

被引:13
作者
PATTERSON, SE
JANDA, L
STREKOWSKI, L
机构
[1] Department of Chemistry, Georgia State University, Atlanta, Georgia
关键词
D O I
10.1002/jhet.5570290405
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A one-pot preparation of carboximidamides (amidines) 11-14 involves treatment of amides 2-5 with phosphorus pentachloride followed by the treatment of the resultant crude imidoyl chlorides 7-10 with ammonia. Amidines 11-14 are cyclized to quinazolines 20-26 in lithium alkylamide- or dialkylamide-mediated reactions.
引用
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页码:703 / 706
页数:4
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