ENHANCED INDUCTION OF LYMPHOKINE-ACTIVATED KILLER ACTIVITY AFTER LENTINAN ADMINISTRATION IN PATIENTS WITH GASTRIC-CARCINOMA

被引：17

作者：

ARINAGA, S

KARIMINE, N

TAKAMUKU, K

NANBARA, S

INOUE, H

NAGAMATSU, M

UEO, H

AKIYOSHI, T

机构：

[1] Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1992年 / 14卷 / 04期

关键词：

D O I：

10.1016/0192-0561(92)90114-Z

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 15 patients with gastric carcinoma, peripheral blood mononuclear cells (PBM) were obtained serially before and 3, 5 and 7 days after lentinan administration. The generation of lymphokine-activated killer (LAK) activity, induced by in vitro activation of PBM with interleukin 2 (IL 2), was significantly augmented 5 days after a single intravenous dose of 2 mg lentinan, when compared with that before lentinan injection. Natural killer (NK) activity of PBM was also significantly enhanced 7 days after the drug injection. However, the distribution of lymphocyte subsets exhibited no significant change following lentinan administration.

引用

页码：535 / 539

页数：5

共 20 条

[1]

ARINAGA S, 1991, INT J IMMUNOPHARMACO, V14, P43

[2]

CHIHARA G, 1970, CANCER RES, V30, P2776

[3] LYMPHOKINE-ACTIVATED KILLER CELL PHENOMENON - LYSIS OF NATURAL KILLER-RESISTANT FRESH SOLID TUMOR-CELLS BY INTERLEUKIN 2-ACTIVATED AUTOLOGOUS HUMAN PERIPHERAL-BLOOD LYMPHOCYTES [J].