VASOPRESSIN ELEVATION OF NA+/H+ EXCHANGE IS INHIBITED BY GENISTEIN IN HUMAN BLOOD-PLATELETS

被引：9

作者：

AHARONOVITS, O ^{[1
]}

ZIK, M ^{[1
]}

LIVNE, AA ^{[1
]}

GRANOT, Y ^{[1
]}

机构：

[1] BEN GURION UNIV NEGEV,DEPT LIFE SCI,IL-84105 BEER SHEVA,ISRAEL

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1112卷 / 02期

关键词：

SODIUM ION-PROTON EXCHANGE; VASOPRESSIN; GENISTEIN; TYROSINE PHOSPHORYLATION; PHORBOL ESTER; STAUROSPORINE; PROTEIN KINASE-C; BLOOD PLATELET; (HUMAN);

D O I：

10.1016/0005-2736(92)90390-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of intracellular Na+ and pH(i) in human blood platelets is known to be controlled by the function of the Na+/H+ exchanger. The phosphorylation state of the Na+/H+ exchanger which determines the exchanger activity in human blood platelets is regulated by the activities of protein kinases and protein phosphatases. Observations in this study indicate that arginine vasopressin (AVP) that interacts with a V1 receptor, activates the Na+/H+ exchange in human blood platelets through a genistein-inhibited mechanism. The AVP-activated Na+/H+ exchange is probably not regulated by protein kinase C (PKC), since this activation is not inhibited by staurosporine. The multiple ways in which platelet Na+/H+ exchange can be modulated may indicate the critical role played by this exchanger in the homeostasis control of pH(i) in human blood platelets.

引用

页码：181 / 186

页数：6

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