GROWTH OF ESCHERICHIA-COLI IN HUMAN URINE - ROLE OF SALT TOLERANCE AND ACCUMULATION OF GLYCINE BETAINE

被引:32
作者
KUNIN, CM
HUA, TH
WHITE, LV
VILLAREJO, M
机构
[1] OHIO STATE UNIV,DEPT INTERNAL MED,COLUMBUS,OH 43210
[2] UNIV CALIF DAVIS,DEPT BIOCHEM & BIOPHYS,DAVIS,CA 95616
关键词
D O I
10.1093/infdis/166.6.1311
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Glycine betaine is a powerful osmoprotectant molecule present in the inner medulla of the kidney and excreted into urine. It may be responsible for the ability of Escherichia coli to grow in hypertonic urine. Also, strains of E. coli that cause urinary tract infections may be more salt-tolerant than strains from other sites. To explore these questions, 301 isolates from blood, urine, or stool and 12 representative enteric strains were examined. Tolerance varied from 0. 1 to 0.7 M NaCl (median, 0.5) in minimal medium. There were no significant differences in salt tolerance by site of isolation. A salt-sensitive enteric strain that responded poorly to glycine betaine and mutant strains lacking the ability to synthesize or transport glycine betaine did not grow well in hypertonic urine. Accumulation of glycine betaine appears to be a mechanism by which E. coli can adapt to external osmotic forces and grow in hypertonic urine.
引用
收藏
页码:1311 / 1315
页数:5
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