SOME PHARMACEUTICAL PROPERTIES OF 2,3,6-PARTIALLY METHYLATED-BETA-CYCLODEXTRIN AND ITS SOLUBILIZING AND STABILIZING ABILITIES

被引：11

作者：

OU, D

UEDA, H

NAGASE, H

ENDO, T

NAGAI, T

机构：

[1] HOSEI UNIV,DEPT PHYS CHEM,SHINAGAWA KU,TOKYO 142,JAPAN

[2] HOSEI UNIV,DEPT PHARMACEUT,SHINAGAWA KU,TOKYO 142,JAPAN

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1994年 / 20卷 / 12期

关键词：

D O I：

10.3109/03639049409049333

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The pharmaceutical properties of 2,3,6-partially methylated-beta-cyclodextrin(PMCD) were investigated. The aqueous solubility bf PMCD was much higher than that of the parent beta-CyD, and it exhibited endothermic dissolution in contrast to that of the conventional heptakis-(2,6-di-O- methyl)-beta-cyclodextrin(DMCD). The acid-catalyzed hydrolysis rate of PMCD was faster than those of the parent beta-CyD and DMCD. The hemolytic activity(human erythrocytes) of PMCD was similar to that of DMCD. PMCD was a more effective solubilizer for poorly water-soluble drugs than the parent beta-CyD; however PMCD is not as effective as DMCD. The stabilizing effect of PMCD on chemically unstable drugs was higher than that of the parent beta-CyD.

引用

页码：2005 / 2016

页数：12