DISTRIBUTION OF NITRIC-OXIDE SYNTHASE IN THE CENTRAL-NERVOUS-SYSTEM OF MACACA-FUSCATA - SUBCORTICAL REGIONS

被引:43
作者
SATOH, K
ARAI, R
IKEMOTO, K
NARITA, M
NAGAI, T
OHSHIMA, H
KITAHAMA, K
机构
[1] FUJITA HLTH UNIV,DEPT ANAT,TOYOAKE,AICHI,JAPAN
[2] OSAKA UNIV,SCH MED,DEPT PEDIAT,SUITA,OSAKA,JAPAN
[3] WHO,INT AGCY RES CANC,LYON,FRANCE
[4] UNIV LYON 1,DEPT EXPTL MED,LYON,FRANCE
关键词
D O I
10.1016/0306-4522(95)00040-P
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The distribution of nitric oxide synthase-immunoreactive neurons was studied in the Macaca fuscata by immunohistochemistry using antiserum against nitric oxide synthase. In the macaque lower brainstem, many nitric oxide synthase-containing cell bodies were found in the gigantocellular and parvocellular reticular nuclei, the nucleus of the spinal tract of trigeminal nerve, the cochlear nucleus, the prepositus hypoglossi and the nucleus of the solitary tract. Many nitric oxide synthase-immunoreactive perikarya were observed in the laterodorsal-pedunculopontine tegmental nucleus complex of the macaque pontine and midbrain tegmentum. In addition, there were many highly immunoreactive cell bodies in the superficial layers of the inferior and superior colliculi. In the forebrain, numerous cell bodies were observed in the caudate nucleus, putamen, nucleus accumbens, nucleus of the diagonal band, anterior perforated substance and amygdaloid complex. Whereas most of these neurons were labeled highly intense for nitric oxide synthase, there were also many lightly labeled nitric oxide synthase-immunoreactive neurons in the substantia innominata, globus pallidus, ansa peduncularis and lateral hypothalamic nucleus. The present observation indicated some species difference in the distribution of central nitric oxide synthase-containing neurons. Furthermore, the present neuroanatomical evidence that nitric oxide synthase is distributed in a variety of specific neuronal systems, with some differences in the patterns of cytoplasmic localization, further indicates the neural messenger role of nitric oxide in the central nervous system.
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页码:685 / 696
页数:12
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