SYNTHESIS, ANTILEUKEMIC EVALUATION AND PEROXIDATING ABILITY OF HETEROSUBSTITUTED ANTHRACENE-9,10-DIONE ANALOGS - 5,8-[(AMINOALKYL)AMINO]NAPHTHO[2,3-D]THIAZOLE-4,9-DIONES AND 5,8-[(AMINOALKYL)AMINO]NAPHTHO[2,3-C][1,2,5]THIADIAZOLE-4,9-DIONES

The syntheses of a number of heterosubstituted ametantrone analogues, 5,8-bis[(aminoalkyl)amino]naphtho[2,3-d]thia- zole-4,9-diones and 5,8-bis[(aminoalkyl)amino]naphtho[2,3-c] [1,2,5]thiadiazole-4,9-diones, have been performed. It was evidenced that this modification in the chromophore moiety has a negative effect on antileukemic activity. This modification also favors the affinity of the compounds toward NADH dehydrogenase and influences the redox potential.