RHIZOBIUM-SYNTHESIZED PHYTOTOXIN - AN INHIBITOR OF BETA-CYSTATHIONASE IN SALMONELLA TYPHIMURIUM

被引：56

作者：

OWENS, LD

GUGGENHEIM, S

HILTON, JL

机构：

[1] U.S. Soils Laboratory, Soil and Water Conservation Research Division, Agricultural Research Service, Beltsville, Md

[2] Laboratory Biochemistry, National Heart Institute, Bethesda, Md

[3] Crops Research Division, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1968年 / 158卷 / 02期

关键词：

D O I：

10.1016/0304-4165(68)90134-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rhizobitoxine, a phytotoxin synthesized by Rhizobium japonicum, inhibited the growth of Salmonella typhimurium wild-type and methionine-requiring mutant me-B on a medium supplemented with cystathionine. Neither strain was inhibited by the toxin when the medium was supplemented with homocysteine or methionine. Salmonella β-cystathionase was inhibited by very low concentrations of rhizobitoxine. Cystathionine γ-synthase and Neurospora γ-cystathionase were also inhibited, but at toxin concentrations 1000 times higher. These results indicate that growth inhibition is caused by a methionine deficiency induced by rhizobitoxine inhibition of β-cystathionase. © 1968.

引用

页码：219 / +

页数：1

共 15 条

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