DIFFERENTIAL PULSE POLAROGRAPHIC ANALYSIS OF THYROID-HORMONE - DETERMINATION OF IODINE, THYROXINE, AND LIOTHYRONINE

被引：9

作者：

HOLAK, W

SHOSTAK, D

机构：

[1] Food and Drug Administration, Department of Health, Education, and Welfare, Brooklyn, New York

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 03期

关键词：

Iodine—differential pulse polarographic analysis in thyroid hormone and tablets; Liothyronine—differential pulse polarographic analysis in thyroid hormone and tablets; Polarography; differential pulse—analysis of iodine; thyroxine; and liothyronine in thyroid hormone and tablets; Thyroid—differential pulse polarographic analysis of iodine; and liothyronine in hormone and tablets; Thyroxine—differential pulse polarographic analysis in thyroid hormone and tablets;

D O I：

10.1002/jps.2600680322

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A differential pulse polarographic method for the analysis of thyroid and thyroid tablets for total iodine, thyroxine, and liothyronine is described. The procedure for iodine, which is also applicable to individual tablet assay, consists of ashing the sample, converting iodide to iodate, and analyzing by differential pulse polarography. The procedure for thyroxine and liothyronine involves hydrolysis of the sample with barium hydroxide and isolation and separation of the iodoamino acids using ion exchangers, followed by differential pulse polarographic determination in a supporting electrolyte composed of 0.5 N Na2CO3 in 20% 2‐propanol containing 1% tetrabutylammonium bromide. The differential pulse polarographic results for iodine agree with values obtained using the USP XIX procedure, and the quantities of thyroxine and liothyronine found agree with literature values. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：338 / 342

页数：5

共 6 条

[1] THE DETERMINATION OF THYROXINE WITH SPECIAL REFERENCE TO TABLETS [J].