EFFECT OF CHITOSAN ON LINGUAL HEMOSTASIS IN RABBITS

被引：64

作者：

KLOKKEVOLD, PR ^{[1
]}

LEW, DS ^{[1
]}

ELLIS, DG ^{[1
]}

BERTOLAMI, CN ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,SCH DENT,ORAL & MAXILLOFACIAL SURG SECT,LOS ANGELES,CA 90024

来源：

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 1991年 / 49卷 / 08期

关键词：

D O I：

10.1016/0278-2391(91)90017-G

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Bleeding times were measured for bilateral (15 mm × 2 mm) tongue incisions in 14 New Zealand white rabbits. Using a randomized, blinded experimental design, one incision in each animal was treated with chitosan and the other was treated with control vehicle without chitosan. Extraoral bleeding and coagulation times were also measured for each animal preoperatively, postoperatively, and prior to killing to verify normal bleeding parameters and to evaluate possible systemic effects associated with topical application. Comparison of lingual incisions receiving the experimental substance versus those receiving control solution showed enhanced hemostasis manifested by a 32% (P < .05) decrease in bleeding time. © 1991.

引用

页码：858 / 863

页数：6

共 9 条

[1] CHITOSAN - A NEW TOPICAL HEMOSTATIC AGENT FOR DIFFUSE CAPILLARY BLEEDING IN BRAIN-TISSUE [J].

BRANDENBERG, G ;

LEIBROCK, LG ;

SHUMAN, R ;

MALETTE, WG ;

QUIGLEY, H .

NEUROSURGERY, 1984, 15 (01) :9-13

[2]

COLES EH, 1974, CLIN PATHOLOGY, P157

[3]

DUGDALE M, 1983, DENT CLIN N AM, V27, P271

[4] MANAGEMENT OF DENTAL PATIENTS WITH BLEEDING DISORDERS - REVIEW AND UPDATE [J].

JOHNSON, WT ;

LEARY, JM .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 1988, 66 (03) :297-303

[5]

KIND G M, 1990, Current Surgery, V47, P37

[6] CHITOSAN - A NEW HEMOSTATIC [J].

MALETTE, WG ;

QUIGLEY, HJ ;

GAINES, RD ;

JOHNSON, ND ;

RAINER, WG .

ANNALS OF THORACIC SURGERY, 1983, 36 (01) :55-58

[7]

MUZZARELLI RAA, 1986, CHITIN NATURE TECHNO, P507

[8] TOOTH EXTRACTIONS IN HEMOPHILIACS [J].

RAMSTROM, G ;

BLOMBACK, M .

INTERNATIONAL JOURNAL OF ORAL SURGERY, 1975, 4 (01) :1-17

[9]

TAVENNER RWH, 1968, BR DENT J, V2, P19

← 1 →