THE CALCIUM-ANTAGONIST PN200-110 INHIBITS THE REINFORCING PROPERTIES OF COCAINE

被引：75

作者：

PANI, L ^{[1
]}

KUZMIN, A ^{[1
]}

MARTELLOTTA, MC ^{[1
]}

GESSA, GL ^{[1
]}

FRATTA, W ^{[1
]}

机构：

[1] UNIV CAGLIARI,BB BRODIE DEPT NEUROSCI,VIA PORCELL 4,I-09124 CAGLIARI,ITALY

来源：

BRAIN RESEARCH BULLETIN | 1991年 / 26卷 / 03期

关键词：

COCAINE; DOPAMINE; CALCIUM ANTAGONISTS; PN200-110; LOCOMOTOR ACTIVITY; CONDITIONED PLACE PREFERENCE;

D O I：

10.1016/0361-9230(91)90022-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of a dihydropyridine (DHP) calcium antagonist, PN 200-110, on cocaine reinforcing properties was investigated using conditioned place preference paradigm. PN 200-110 in nonsedative doses (0.62-1.25-2.5 mg/kg SC) was able to inhibit cocaine- (10 mg/kg IP) induced place preference with ED50 1.57 (0.88-2.58). The results suggest a possible use of DHPs in the treatment of cocaine-related disorders.

引用

页码：445 / 447

页数：3

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