DETERMINATION OF CISPLATIN AND SOME POSSIBLE METABOLITES BY ION-PAIRING CHROMATOGRAPHY WITH INDUCTIVELY-COUPLED PLASMA-MASS SPECTROMETRIC DETECTION

被引：63

作者：

ZHAO, Z

TEPPERMAN, K

DORSEY, JG

ELDER, RC

机构：

[1] UNIV CINCINNATI, BIOMED CHEM RES CTR, DEPT CHEM, CINCINNATI, OH 45221 USA

[2] UNIV CINCINNATI, BIOMED CHEM RES CTR, DEPT BIOL SCI, CINCINNATI, OH 45221 USA

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 615卷 / 01期

关键词：

D O I：

10.1016/0378-4347(93)80293-D

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive method is described for measuring cisplatin and some possible metabolites. The method combines reversed-phase ion-pairing liquid chromatography (LC) with inductively coupled plasma mass spectrometry (ICP-MS) for platinum-specific detection. Separation conditions for cisplatin hydrolysis products and the reaction products of cisplatin with methionine, cysteine, and glutathione have been investigated with sodium dodecylsulfate or heptanesulfonate as the ion-pairing agent. The detection limit for cisplatin was found to be 0.1 ng, corresponding to a concentration detection limit of 1 ng/ml when using an injection volume of 100 mul. This study has demonstrated the usefulness of LC-ICP-MS for cisplatin metabolism studies.

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页码：83 / 89

页数：7

相关论文

共 28 条

[1] EVALUATION OF INDUCTIVELY COUPLED MASS-SPECTROMETRY FOR THE DETERMINATION OF PLATINUM IN PLASMA [J].

ALLAIN, P ;

BERRE, S ;

MAURAS, Y ;

LEBOUIL, A .

BIOLOGICAL MASS SPECTROMETRY, 1992, 21 (03) :141-143

[2] DETERMINATION OF CISPLATIN AND RELATED PLATINUM COMPLEXES IN PLASMA ULTRAFILTRATE AND URINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ONLINE RADIOACTIVITY DETECTION [J].

BALDEW, GS ;

VOLKERS, KJ ;

DEGOEIJ, JJM ;

VERMEULEN, NPE .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1989, 491 (01) :163-174

[3] EVALUATION OF REDUCTIVE AMPEROMETRIC DETECTION IN THE LIQUID-CHROMATOGRAPHIC DETERMINATION OF ANTI-NEOPLASTIC PLATINUM COMPLEXES [J].

BANNISTER, SJ ;

STERNSON, LA ;

REPTA, AJ .

JOURNAL OF CHROMATOGRAPHY, 1983, 273 (02) :301-318

[4]

CASETTA B, 1991, ATOM SPECTROSC, V12, P81

[5] STABILITY OF CISPLATIN, IPROPLATIN, CARBOPLATIN, AND TETRAPLATIN IN COMMONLY USED INTRAVENOUS SOLUTIONS [J].

CHEUNG, YW ;

CRADOCK, JC ;

VISHNUVAJJALA, BR ;

FLORA, KP .

AMERICAN JOURNAL OF HOSPITAL PHARMACY, 1987, 44 (01) :124-130

[6] A STUDY OF THE PROTECTIVE EFFECT OF CHLORIDE SALTS ON CISPLATIN NEPHROTOXICITY [J].

DALEYYATES, PT ;

MCBRIEN, DCH .

BIOCHEMICAL PHARMACOLOGY, 1985, 34 (13) :2363-2369

[7] CISPLATIN METABOLITES IN PLASMA, A STUDY OF THEIR PHARMACOKINETICS AND IMPORTANCE IN THE NEPHROTOXIC AND ANTITUMOUR ACTIVITY OF CISPLATIN [J].

DALEYYATES, PT ;

MCBRIEN, DCH .

BIOCHEMICAL PHARMACOLOGY, 1984, 33 (19) :3063-3070

[8] ANALYSIS OF PLATINUM SPECIES ORIGINATING FROM CIS-DIAMMINEDICHLOROPLATINUM(II) (CISPLATIN) IN HUMAN AND RAT PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ONLINE INDUCTIVELY COUPLED PLASMA ATOMIC EMISSION SPECTROMETRIC DETECTION [J].

DEWAAL, WAJ ;

MAESSEN, FJMJ ;

KRAAK, JC .

JOURNAL OF CHROMATOGRAPHY, 1987, 407 :253-272

[9] EFFICIENCY ENHANCEMENT IN MICELLAR LIQUID-CHROMATOGRAPHY [J].

DORSEY, JG ;

DEECHEGARAY, MT ;

LANDY, JS .

ANALYTICAL CHEMISTRY, 1983, 55 (06) :924-928

[10] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF PLATINUM(II) IN PLASMA ULTRAFILTRATE AND URINE - COMPARISON WITH A FLAMELESS ATOMIC-ABSORPTION SPECTROMETRIC METHOD [J].

DRUMMER, OH ;

PROUDFOOT, A ;

HOWES, L ;

LOUIS, WJ .

CLINICA CHIMICA ACTA, 1984, 136 (01) :65-74