FUNCTIONAL AND PHENOTYPIC ANALYSIS OF T-LYMPHOCYTES IN LARYNGEAL CARCINOMA

被引：6

作者：

GONZALEZ, FM ^{[1
]}

VARGAS, JA ^{[1
]}

GEABANACLOCHE, JC ^{[1
]}

GARCIA, JR ^{[1
]}

BERROCAL, E ^{[1
]}

GORRIZ, C ^{[1
]}

DURANTEZ, A ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID, CLIN PUERTA HIERRO, SERV INTERNAL MED 1, E-28035 MADRID, SPAIN

来源：

ACTA OTO-LARYNGOLOGICA | 1994年 / 114卷 / 06期

关键词：

LARYNGEAL CARCINOMA; T-LYMPHOCYTES; FLOW-CYTOMETRIC; PROLIFERATION;

D O I：

10.3109/00016489409126123

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

We studied the functional response and phenotypic characterization of peripheral blood T cells and their correlation with the clinical stage of disease in 29 males with previously untreated carcinoma of the larynx and 24 healthy male controls. Peripheral blood T cells, phenotypically CD2+CD3+, were significantly decreased in the patients relative to the controls. Patients with advanced locoregional extension (T4 and N1, 2, 3) also showed a diminution of the CD4+ subpopulation of T cells. DNA synthesis by purified T cells showed similar blastogenic responses in patients and controls; the interleukin-2 production of phytohemagglutinin stimulated lymphocytes was also normal. We conclude that in patients with laryngeal carcinoma there is a phenotypic alteration of the T cells that is variable according to tumor stage, without functional alterations in blastogenic capacity or IL-2 production.

引用

页码：663 / 668

页数：6

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