FERTILIZATION - UTERINE GLYCOSAMINOGLYCAN STIMULATES THE CONVERSION OF SPERM PROACROSIN TO ACROSIN

被引：45

作者：

WINCEK, TJ ^{[1
]}

PARRISH, RF ^{[1
]}

POLAKOSKI, KL ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT OBSTET & GYNECOL,ST LOUIS,MO 63110

来源：

SCIENCE | 1979年 / 203卷 / 4380期

关键词：

D O I：

10.1126/science.32621

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Acrosin is a proteinase required for mammalian fertilization, and in freshly ejaculated spermatozoa exists as an inactive zymogen, proacrosin. A factor present in uterine flushings of gilts stimulates the conversion of highly purified boar proacrosin to acrosin. Characterization of this factor indicates that its active component is a glycosaminoglycan. Copyright © 1979 AAAS.

引用

页码：553 / 554

页数：2

共 15 条

[1]

Bedford J. M., 1970, Biology Reprod., VNo. 2, P128, DOI 10.1095/biolreprod2.Supplement_2.128

[2]

ESBANSHADE K, 1977, THESIS PURDUE U

[3]

HOMBURGER F, 1963, ANN NY ACAD SCI, V106, P683

[4]

HUNTER RHF, 1968, J REPROD FERTIL, V15, P199, DOI 10.1530/jrf.0.0150199

[5]

LUDOWIEG J, 1961, J BIOL CHEM, V236, P333

[6]

MCKAY DG, 1950, AM J OBSTET GYNECOL, V59, P875

[7] BIOCHEMISTRY OF MAMMALIAN FERTILIZATION [J].

MCRORIE, RA ;

WILLIAMS, WL .

ANNUAL REVIEW OF BIOCHEMISTRY, 1974, 43 :777-803

[8] PROACROSIN FROM RABBIT EPIDIDYMAL SPERMATOZOA - PARTIAL-PURIFICATION AND INITIAL BIOCHEMICAL CHARACTERIZATION [J].

MEIZEL, S ;

MUKERJI, SK .

BIOLOGY OF REPRODUCTION, 1975, 13 (01) :83-93

[9]

PARRISH RF, 1978, FED PROC, V37, P1795

[10] PHOSPHOLIPID VESICLE STIMULATION OF PROACROSIN ACTIVATION [J].

PARRISH, RF ;

STRAUS, JW ;

POLAKOSKI, KL ;

DOMBROSE, FA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (01) :149-152

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