LOSS OF LETS PROTEIN IS NOT A MARKER FOR SALIVARY-GLAND OR BLADDER EPITHELIAL-CELL TRANSFORMATION

LETS protein was demonstrated by indirect immunofluorescence techniques in adult mouse submandibular gland and bladder epithelial cells at various stages during neoplastic transformation, after the application of a chemical carcinogen in vitro. There was no clear relationship between transformation and the loss of LETS protein; most normal and preneoplastic epithelium lacked the distinctive fibrillar distribution of fluorescent staining. In contrast, some carcinoma-producing cell lines did possess appreciable amounts of LETS protein. © 1979.