STRIOSOMAL ORGANIZATION OF CHOLINERGIC AND DOPAMINERGIC UPTAKE SITES AND CHOLINERGIC-M1 RECEPTORS IN THE ADULT HUMAN STRIATUM - A QUANTITATIVE RECEPTOR AUTORADIOGRAPHIC STUDY

被引：34

作者：

LOWENSTEIN, PR

JOYCE, JN

COYLE, JT

MARSHALL, JF

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT PEDIAT PHARMACOL & NEUROSCI,DIV CHILD PSYCHIAT,BALTIMORE,MD 21205

[2] UNIV PENN,SCH MED,DEPT PSYCHIAT,PHILADELPHIA,PA 19104

[3] UNIV CALIF IRVINE,DEPT PSYCHOBIOL,IRVINE,CA 92717

来源：

BRAIN RESEARCH | 1990年 / 510卷 / 01期

关键词：

Cholinergic marker; Compartment; Dopaminergic marker; Human; Striatum;

D O I：

10.1016/0006-8993(90)90736-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of cholinergic pre- and postsynaptic markers and dopaminergic presynaptic markers was analyzed in the adult human striatum, using quantitative receptor autoradiography. The distribution of the different binding sites indicates that cholinergic and dopaminergic uptake sites display a striosomal organization, with a higher binding site density in the striatal matrix. M1 muscarinic cholinergic receptor distribution parallels the distribution of cholinergic presynaptic markers. Our data show that cholinergic and dopaminergic terminals, and M1 receptors are enriched in the matrix of the adult human striatum. © 1990.

引用

页码：122 / 126

页数：5

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