A SIMPLE AND STEREOCONTROLLED SYNTHESIS OF A 1-BETA-METHYLCARBAPENEM KEY INTERMEDIATE BY MEANS OF ORGANOSILICON CHEMISTRY

被引：30

作者：

UYEO, S

ITANI, H

机构：

[1] Shionogi Research Laboratories, Shionogi and Co., Ltd., Fukushima-ku, Osaka

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(00)71259-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and stereocontrolled synthesis of 1, starting from the acetoxy-azetidinone 5 via N-(Z)-crotylsilane compound 7, was developed.

引用

收藏

页码：2143 / 2144

页数：2

相关论文

共 10 条

[1] PRACTICAL PREPARATION OF 4(R)-ALLYLAZETIDINONES AND 4(R)-(1-METHYLALLYL)AZETIDINONES
FLIRI, H
MAK, CP
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (19) : 3438 - 3442
[2] HARUTA J, 1989, CHEM PHARM BULL, V37, P2338
[3] IMUTA M, IN PRESS CHEM PHARM
[4] A HIGHLY STEREOSELECTIVE SYNTHESIS OF A KEY INTERMEDIATE OF 1-BETA-METHYLCARBAPENEMS EMPLOYING THE REFORMATSKY REACTION OF 3-(2-BROMOPROPIONYL)-2-OXAZOLIDONE DERIVATIVES
ITO, Y
TERASHIMA, S
[J]. TETRAHEDRON LETTERS, 1987, 28 (52) : 6625 - 6628
[5] PRASAD JS, 1987, TETRAHEDRON LETT, V28, P1857
[6] SALIMGAREEVA IM, 1980, IAN SSSR KH, V2, P407
[7] SALZMANN TN, 1989, ROYAL SOC CHEM SPECI, V70, P171
[8] THE SYNTHESIS OF 2-(FUNCTIONALIZED METHYL)-1-BETA-METHYLCARBAPENEMS
SCHMITT, SM
SALZMANN, TN
SHIH, DH
CHRISTENSEN, BG
[J]. JOURNAL OF ANTIBIOTICS, 1988, 41 (06) : 780 - 787
[9] SHIH DH, 1984, HETEROCYCLES, V21, P29
[10] A NOVEL CARBAPENEM ANTIBIOTIC, SM-7338 STRUCTURE-ACTIVITY-RELATIONSHIPS
SUNAGAWA, M
MATSUMURA, H
INOUE, T
FUKASAWA, M
KATO, M
[J]. JOURNAL OF ANTIBIOTICS, 1990, 43 (05) : 519 - 532