TIME COURSE OF K+ CURRENT INHIBITION BY LOW OXYGEN IN CHEMORECEPTOR CELLS OF ADULT-RABBIT CAROTID-BODY - EFFECTS OF CARBON-MONOXIDE

被引：70

作者：

LOPEZLOPEZ, JR ^{[1
]}

GONZALEZ, C ^{[1
]}

机构：

[1] UNIV VALLADOLID, FAC MED, DEPT BIOQUIM & BIOL MOLEC & FISIOL, E-47005 VALLADOLID, SPAIN

来源：

FEBS LETTERS | 1992年 / 299卷 / 03期

关键词：

CAROTID BODY; CHEMORECEPTOR CELL; K+ CURRENT; LOW PO2; CARBON MONOXIDE; OXYGEN SENSOR;

D O I：

10.1016/0014-5793(92)80126-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

K+ currents recorded from adult rabbit chemoreceptor cells are reversibly inhibited on lowering the pO2 in the bathing solution. Bath application of a hypoxic TTX-containing solution revealed that inhibition of K+ current by low pO2 proceeds faster than TTX inhibition of Na+ currents, the apparent t1/2 being 3.68 and 7.14 s, respectively. Addition of carbon monoxide to the hypoxic gas mixture used to equilibrate the bathing solution reversed the inhibition of K+ currents by approx. 70%.

引用

页码：251 / 254

页数：4

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