CHROMOSOME-ABNORMALITIES IN BONE-MARROW OF FANCONI ANEMIA PATIENTS

被引：27

作者：

BERGER, R

LECONIAT, M

SCHAISON, G

机构：

[1] HOP ST LOUIS,INST GENET MOLEC,INSERM,U301,F-75010 PARIS,FRANCE

[2] HOP ST LOUIS,INST GENET MOLEC,CNRS,SDI 15954 I,F-75010 PARIS,FRANCE

[3] HOP ST LOUIS,UNITE HEMATOL PEDIAT,F-75010 PARIS,FRANCE

来源：

CANCER GENETICS AND CYTOGENETICS | 1993年 / 65卷 / 01期

关键词：

D O I：

10.1016/0165-4608(93)90057-S

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the clonal chromosome abnormalities of five patients with Fanconi anemia (FA). In one with myelodysplastic syndrome (MDS), an abnormal clone was present in the bone marrow (BM): 47,XY,trp(1)(q32q44), +mar. Two had acute myeloblastic leukemia (AML), one with monosomy 7 and the other with 46,XYadd(1)(p34),del(7)(p13). In the two others without signs of MDS or AML, pseudodiploidy with 46,XX, -5,+8 and 46,XX, +5,-21 were present, respectively. The significance of these abnormalities is discussed.

引用

页码：47 / 50

页数：4

共 19 条

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