ROLE OF SEROTONIN IN THE REGULATION OF INTERFERON-GAMMA PRODUCTION BY HUMAN NATURAL-KILLER-CELLS

被引：42

作者：

HELLSTRAND, K ^{[1
]}

CZERKINSKY, C ^{[1
]}

RICKSTEN, A ^{[1
]}

JANSSON, B ^{[1
]}

ASEA, A ^{[1
]}

KYLEFJORD, H ^{[1
]}

HERMODSSON, S ^{[1
]}

机构：

[1] GOTHENBURG UNIV, INST MED MICROBIOL, S-41346 GOTHENBURG, SWEDEN

来源：

JOURNAL OF INTERFERON RESEARCH | 1993年 / 13卷 / 01期

关键词：

D O I：

10.1089/jir.1993.13.33

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monocytes, recovered directly from peripheral blood by counter-current centrifugal elutriation (CCE), were shown to provide two regulatory signals for induction of interferon-gamma (IFN-gamma) in natural killer (NK) cells in response to interleukin-2 (IL-2): an upregulating signal and an inhibitory signal. The inhibitory signal was time-dependent, irreversible, and operating on a pretranslational level, as indicated by the inability of enriched NK cells to accumulate IFN-gamma mRNA in the presence of elutriated monocytes. Monocyte-induced inhibition of IFN-gamma production was abrogated by the biogenic amine serotonin, acting via the 5-hydroxy-tryptamine, or serotonin (5-HT1A), subset of serotonin receptors (5-HTR). Thereby, serotonin effectively promoted IFN-gamma production in the presence of monocytes. We conclude that serotonergic 5-HT1A receptors transduce signals that are required for NK cells to produce IFN-gamma in response to IL-2.

引用

页码：33 / 38

页数：6

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