COMPARTMENTAL ANALYSIS OF THE PHARMACOKINETICS OF RADIOIODINATED MONOCLONAL-ANTIBODY B72.3 IN COLON CANCER-PATIENTS

被引：5

作者：

REILLY, RM

KIRSH, J

GALLINGER, S

THIESSEN, JJ

DAMANI, M

HAY, K

POLIHRONIS, J

SCHMOCKER, B

ODZE, R

HOULE, S

STERN, H

机构：

[1] MT SINAI HOSP,DEPT NUCL MED,TORONTO M5G 2C4,ONTARIO,CANADA

[2] MT SINAI HOSP,DEPT SURG,TORONTO M5G 2C4,ONTARIO,CANADA

[3] MT SINAI HOSP,DEPT PATHOL,TORONTO M5G 2C4,ONTARIO,CANADA

[4] UNIV TORONTO,FAC PHARM,TORONTO M5G 2C4,ONTARIO,CANADA

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1993年 / 20卷 / 01期

关键词：

D O I：

10.1016/0969-8051(93)90136-I

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Sixteen patients with colorectal cancer were administered 37-74 MBq (1 mg) of radioiodinated B72.3 monoclonal antibody. Pharmacokinetic analysis was carried out on plasma and urine samples. Elimination from the plasma was biexponential with a mean T1/2alpha of 3.7 h and T1/2beta of 62.4 h. The plasma clearance was fit to a two-compartment model. This was combined with a previously reported model for radioiodine to construct a composite model. There was a good correlation (r = 0.952) between the model-predicted and observed excretion of radioiodine suggesting that the composite model is compatible with the pharmacokinetics of the radiolabelled antibody.

引用

页码：57 / 64

页数：8

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