INHIBITION OF NITRIC-OXIDE SYNTHASE DRAMATICALLY POTENTIATES SEIZURES INDUCED BY KAINIC ACID AND PILOCARPINE IN RATS

被引：67

作者：

MAGGIO, R

FUMAGALLI, F

DONATI, E

BARBIER, P

RACAGNI, G

CORSINI, GU

RIVA, M

机构：

[1] UNIV MILAN,INST PHARMACOL SCI,CTR NEUROPHARMACOL,MILAN,ITALY

[2] ASSOC ANNI VERDI,I-00152 ROME,ITALY

[3] HOSP SAN RAFFAELE,DIBIT,MILAN,ITALY

来源：

BRAIN RESEARCH | 1995年 / 679卷 / 01期

关键词：

NITRIC OXIDE; SEIZURE; PILOCARPINE; KAINIC ACID; N-METHYL-D-ASPARTATE RECEPTOR; NITRO-L-ARGININE;

D O I：

10.1016/0006-8993(95)00217-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with N-W-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.

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页码：184 / 187

页数：4

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