STRIATAL 3,4-DIHYDROXYPHENYLALANINE DECARBOXYLASE IN AGING - DISPARITY BETWEEN POSTMORTEM AND POSITRON EMISSION TOMOGRAPHY STUDIES

被引:71
作者
KISH, SJ
ZHONG, XH
HORNYKIEWICZ, O
HAYCOCK, JW
机构
[1] UNIV VIENNA,INST BIOCHEM PHARMACOL,VIENNA,AUSTRIA
[2] LOUISIANA STATE UNIV,MED CTR,DEPT BIOCHEM & MOLEC BIOL,NEW ORLEANS,LA
关键词
D O I
10.1002/ana.410380220
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Recent positron emission tomography (PET) studies using 3,4-[F-18] fluorodihydroxyphenylalanine ([F-18]fluorodopa) have reported little or no decrement in dopaminergic function in human striatum (caudate and putamen) during aging. In contrast, previous postmortem studies have reported marked age-dependent decreases in the activity of dopa decarboxylase (DDC), a variable upon which the PET determinations depend. Using quantitative blot immunolabeling techniques, we measured DDC protein concentrations in postmortem striata of 28 neurologically normal subjects ranging in age from 17 to 103 years. We found a significant, albeit modest, age-dependent decrease in the concentration of DDC protein in caudate (r = -0.50, p < 0.05) but not in putamen (r = -0.16, p > 0.05), with mean values of the 87-year-old group being 27% (caudate) and 12% (putamen) lower than those of the 30-year-old group, The absence of a robust effect of aging upon striatal DDC protein is consistent with the [F-18]fluorodopa-PET studies that report either no change or only a relatively small decrease in striatal F-18 accumulation during aging. To the extent that aging is associated with a substantial loss of striatal dopaminergic nerve terminals, the present results also suggest that DDC protein synthesis may be upregulated in those dopaminergic neurons that survive the aging process and, therefore, that striatal [F-18]fluorodopa uptake indices may provide an overestimate of the number of dopaminergic nerve terminals during physiological aging.
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页码:260 / 264
页数:5
相关论文
共 31 条
[1]   POSTMORTEM CHANGES IN BRAIN CATECHOLAMINE ENZYMES [J].
BLACK, IB ;
GEEN, SC .
ARCHIVES OF NEUROLOGY, 1975, 32 (01) :47-49
[2]  
Bowsher RR, 1986, NEUROMETHODS, V5, P33
[3]   AGE-DEPENDENT DECLINE OF NIGROSTRIATAL DOPAMINERGIC FUNCTION - A POSITRON EMISSION TOMOGRAPHIC STUDY OF GRANDPARENTS AND THEIR GRANDCHILDREN [J].
CORDES, M ;
SNOW, BJ ;
COOPER, S ;
SCHULZER, M ;
PATE, BD ;
RUTH, TJ ;
CALNE, DB .
ANNALS OF NEUROLOGY, 1994, 36 (04) :667-670
[4]  
COTE LJ, 1983, DEMENTIAS, P19
[5]  
CUMMING P, 1994, J NEUROCHEM, V63, P1675
[6]   STRIATAL F-18 DOPA UPTAKE - ABSENCE OF AN AGING EFFECT [J].
EIDELBERG, D ;
TAKIKAWA, S ;
DHAWAN, V ;
CHALY, T ;
ROBESON, W ;
DAHL, R ;
MARGOULEFF, D ;
MOELLER, JR ;
PATLAK, CS ;
FAHN, S .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1993, 13 (05) :881-888
[7]  
EIDELBERG D, 1994, J CEREBR BLOOD F MET, V14, P882, DOI 10.1038/jcbfm.1994.112
[8]   DOPA DECARBOXYLASE ACTIVITY OF THE LIVING HUMAN BRAIN [J].
GJEDDE, A ;
REITH, J ;
DYVE, S ;
LEGER, G ;
GUTTMAN, M ;
DIKSIC, M ;
EVANS, A ;
KUWABARA, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (07) :2721-2725
[9]  
HADJICONSTANTIN.M, 1993, J NEUROCHEM, V60, P2175
[10]   MORPHOMETRY OF THE HUMAN CORTEX CEREBRI AND CORPUS STRIATUM DURING AGING [J].
HAUG, H ;
EGGERS, R .
NEUROBIOLOGY OF AGING, 1991, 12 (04) :336-338